Singular Loci of Schubert Varieties

The final chapter summarizes the results, presents bibliographic comments, and considers future directions in the field.

Employing recent results on elliptic and evolutionary variational inequalities, convex analysis, nonlinear equations with monotone operators, and fixed points of operators, Analysis and Approximation of Contact Problems with Adhesion or Damage places these important tools and results at your fingertips in a unified, accessible reference.

The book places the fundamental tenets of computer programming into the context of MATLAB, employing hands-on exercises, examples from the engineering industry, and a variety of core tools to increase programming proficiency and capability. With this knowledge, students are prepared to adapt learned concepts to other programming languages.

This five-part book begins with a section on basics that covers terminology, the compatibility of partial words, and combinatorial properties of words. The book then focuses on three important concepts of periodicity on partial words: period, weak period, and local period. The next part describes a linear time algorithm to test primitivity on partial words and extends the results on unbordered words to unbordered partial words while the following section introduces some important properties of pcodes, details a variety of ways of defining and analyzing pcodes, and shows that the pcode property is decidable using two different techniques. In the final part, the author solves various equations on partial words, presents binary and ternary correlations, and covers unavoidable sets of partial words.

Setting the tone for future research in this field, this book lucidly develops the central ideas and results of combinatorics on partial words.

The timeliness of a manuscript is more than its form, which may be unfinished or tentative. Thus, in some instances, proofs may be merely outlined and results presented which have been or will later be published elsewhere. If possible, a subject index should be included. Publication of Lecture Notes is intended as a service to the international mathematical community, in that a commercial publisher, Springer-Verlag, can offer a wide distribution of documents which would otherwise have a restricted readership. Once published and copyrighted, they can be documented in the scientific literature.

The book focuses on simple two-stage adaptive designs with sample size re-estimation before moving on to explore more challenging designs and issues that include drop-loser, adaptive dose-funding, biomarker-adaptive, multiple-endpoint adaptive, response-adaptive randomization, and Bayesian adaptive designs. In many of the chapters, the author compares methods and provides practical examples of the designs, including those used in oncology, cardiovascular, and inflammation trials.
Equipped with the knowledge of adaptive design presented in this book, you will be able to improve the efficiency of your trial design, thereby reducing the time and cost of drug development.