Annual Review of Immunology, Volume 36, 2018

While bioinformatics on its own is not enough to accurately assess most new gene variants’ medical significance, studying “gene variants yields important fundamental insights into immunology as well as new, targeted therapies for genetic diseases.”

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The Annual Review of Immunology, in publication since 1983, focuses on basic immune mechanisms and molecular basis of immune diseases in humans. Topics include innate and adaptive immunity; immune cell development and differentiation; immune control of pathogens (viruses, bacteria, parasites) and cancer; and human immunodeficiency and autoimmune diseases.