Dynamic Combinatorial Chemistry

The book presents a pedagogical approach for these state-of-the-art approaches, compiled into a single source for the first time. Ultimately, the volume aims to make valuable research tools accessible to experimentalists and theoreticians alike for any number of scientific efforts, spanning many different types of compounds and reactive conditions.

The ordering of the chapters reflects the natural flow of events in an evolving Universe: Philosophy of Science, the basis of the view that natural events have natural causes – Cosmology, the origin of everything from the Big Bang to the current state of the Universe – Geoscience, the physics and chemistry behind the evolution of the planet Earth from its birth to the present – Life Science, the molecules and mechanisms of life on Earth – Ecology, the interdependence of all components within the Ecosphere and the Universe – Information Content, emphasis on how words and phrases and framing of issues affect opinions, reliability of sources, and the limitations of knowledge.

With development of implants and in vivo detection devices comes the complication of the interaction between the materials used in the devices and biological fluids. This book examines these interactions causing fouling in biosensors and the serious issue of thrombus formation. The chemistry of surface-protein and surface-cell interactions is considered, the coatings and strategies re the avoidance of fouling are compared and the expert contributors provide a comprehensive look at the physical chemistry of the implant surface and the fouling problem.