The Medicinal Chemistry of Glucocorticoid Receptor Modulators :

By (author)Hobson

This book provides an in-depth exploration of the complexities surrounding supply chain globalization, de-globalization, and the prospective re-globalization.

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This book covers the design and development of glucocorticoid receptor modulators (GRM) from cortisol to antibody-drug conjugate payloads over the last 70 years. The author starts with an introduction to the background of glucocorticoid receptor modulators as potential therapeutic modalities. This is followed by seven chapters in which he collates and discusses the medicinal chemistry journey of GRMs, reviewing topics such as cortisol-based glucocorticoids, the different approaches that have been pursued to enable chronic dosing of GRM compounds by inactivation in plasma and the liver, the application of prodrugs to GRMs, selective GRMs, targeted delivery of GRMs using polymers and nanoparticles, and rational drug design approaches applied in the development of GRMs. Particular attention is given to the development of glucocorticoid receptor modulators as immunology antibody-drug conjugate payloads.

SKU: 9783031287312
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Weight 1 kg
Book Author

Hobson

Edition

1st

Format

Paperback

ISBN

9783031287312

Language

English

Pages

152

Publication Year

Publisher

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