Pharmacology and Toxicology Annual Review VOL. 58, 2018

Annual Review of Pharmacology and Toxicology for the invitation to write this article and for the honor of serving on the Committee from 1988 to 2007.

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The Annual Review of Pharmacology and Toxicology, in publication since 1961, covers the significant developments in the fields of pharmacology and toxicology, including receptors, transporters, enzymes, and chemical agents; drug development science; systems such as the immune system, central and autonomic nervous systems, gastrointestinal system, cardiovascular system, endocrine system, and pulmonary system; and special topics.